| چکیده انگلیسی مقاله |
ABSTRACT The importance of the intelligent drug delivery system is evident in cases such as: reducing the frequency of drug use by keeping its amount constant in the blood, reducing the destructive effects of the drug on excretion and persistence in the renal system, and increasing the functional efficiency of the drug compared to traditional and older methods. nowaday The use of efficient drug delivery systems in the combinatorial or multi-drug treatment of complicated diseases for effective and target-specific delivery of therapeutic agents necessitates the use of fast and reliable analytical techniques to reveal the true release profiles of the investigated drugs. The use of mathematical models is very useful in the case of controlled drug delivery systems as this approach enables, the prediction of release kinetics before the release systems are to be realized, and also Often, it can measurement of some important physical parameters, such as the drug diffusion[1,2]. In this work First, Moxifloxacin and Pseudoephedrine were loaded simultaneously on poly (acrylic acid-co2-hydroxyethyl methacrylate) copolymer crosslinked with butane Diol dimethacrylate, and then simultaneous release of two drugs from the polymer substrate in buffer and blood serum sample as a real sample. The results of simultaneous release of drugs were analyzed by MCR-ALS and finally, the obtained profiles with different mathematical models were analyzed by Microsoft Excel Solver. simultaneous release of these drugs was monitored in different pH by the UV-vis spectroscopy. pH=7.3 is chosen as the optimal pH. In order to study the release kinetics, experimental data obtained from in vitro drug release were approximated by several mathematical models including Korsmeyer-Peppas, Ritger-Peppas, zero-order, first-order, and Hixson-Crowell to determine the kinetics of drug release from the polymeric substrate. The results obtained from fitting the curves separated by MCR-ALS with different mathematical models showed that the Korsmayer-Pipas kinetic model has the best results for both drugs and the mechanism of release of both moxifloxacin and Pseudoephedrine drugs from the polymer substrate is non-Fickian diffusion. |
