| چکیده انگلیسی مقاله |
SARC-CoV-2 or covid-19 is a systematic virus infection has speared worldwide since 2019 (1). According to World Health Organization (WHO) the number of people, infected covid-19 is increasing rapidly. Coronavirus pandemic has become a global issue and the mortality rate is on the rise. This virus impairs the body's organ function and expert a significant impact on metabolism but there is little information on how the virus affects metabolism. According to some researches, SARS-CoV-2 primarily causes lung infection through the binding of ACE2 receptors (2). Recognizing the virus characteristics and metabolism can help to provide a safe vaccine. Metabolites are small molecules that their amount in the body or the ratio of some of them change due to cellular metabolism and its disruption indicates the onset of disease and infection (3). The results of research showed metabolomics analysis revealed abnormal levels of some metabolites in the body, so checking the profile of metabolites and finding biomarkers play an important role in covid-19 faster diagnosis. Traditionally, biomarkers play a pivotal role in the early detection of disease etiology, diagnosis, treatment, and prognosis (4). Therefore, to understand the host response to covid-19 and to identify biomarkers in biological samples such as serum, plasma, urine, respiratory gases, saliva, etc. omics science such as transcriptomics, proteomics, and target and untargeted metabolomics (5) based mass spectrometry (6) and nuclear magnetic resonance spectroscopy (7) were used. Based on an article, Benzoate, β-alanine, and 4-chlorobenzene acid were first reported to be used as potential biomarkers to distinguish covid-19 patients from healthy individuals; taurochenodeoxycholic acid 3-sulfate, glucuronate, and N, N, N-trimethyl- alanylproline betaine are the top classifiers in the receiver operating characteristic curve of covid- severe and covid-nonsevere patients (8). Patients with serum levels of Galectin-3 above 35.3 ng/ml had increased risk for mortality (9). Non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify patients with covid-19 (10). Metabolomics analysis in covid-19 patient reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, and the reduction in essential amino acids, tyrosine, and glutamine (11). According to literature, chemometric methods used to analyze obtained data from metabolite profiles. By using chemometric methods like PLS and PCA people classified into a healthy, mild patient and severe patients. In this article, some recent papers about the role of metabolomics in covid-19 reviewed and some metabolites and biomarkers in patients were reported. |
