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هفتمین همایش بیو انفورماتیک ایران
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Chronic inflammation leads ASD children to Cancer |
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| چکیده انگلیسی مقاله |
Autism spectrum disorders (ASDs) are characterized by deficit in ability of Social cognition, emotions and illustrating repetitive behavior [3]. In recent neuropathology studies on children with ASD resolved that there is continues neuroinflammation in their central nerves system (CNS). Furthermore, multi-omic studies proved that ASD and cancer share common genes and molecular mechanisms [1]. Cancer is a complex heterogeneous disease in which a genetic mutation leads to uncontrolled proliferation of the cells. Inflammation is one of the defensive mechanisms against pathogens and establishing tissue homeostasis. Inflammation is also a cancer hallmark, and chronic inflammation have been demonstrated in 25% of cancers. Inflammation contributes to cancer progression and metastasis by creating appropriate conditions such as activating the NFkB signaling pathways and producing inflammatory mediators [2]. Our suggestion is that chronic inflammation increases the risk of cancer in individuals diagnosed with ASD. |
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| کلیدواژه‌های انگلیسی مقاله |
Autism, Cancer, Inflammation, NF-kB |
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| نویسندگان مقاله |
R. Beheshtifar - Masir-e-Sabz clinic, Tehran
M. Shojaee - Masir-e-Sabz clinic, Tehran
M. Moheimani - Masir-e-Sabz clinic, Tehran
Sh. Mohammadi - Masir-e-Sabz clinic, Tehran
F. Taghavi Rad - Islamic Azad University – Ahar branch, Ahar, East Azerbaijan province
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| نشانی اینترنتی |
www.icb7.ir |
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| زبان مقاله منتشر شده |
en |
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