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هفتمین همایش بیو انفورماتیک ایران
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Detection of Critical Genes Associated with Bovine Staphylococcus aureus (S. aureus) Subclinical Mastitis in Dairy Cattle |
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| چکیده انگلیسی مقاله |
Bovine mastitis, is one of the most common diseases of dairy cattle which is responsible for the rate of elimination, low milk yield and poor milk quality; therefore, it induces significant economic losses in the dairy cattle industry [1]. S. aureus, a Gram-positive pathogenic bacterium, is a major subclinical mastitis-causing pathogen in dairy cattle which is usually asymptomatic, persistent, resistant to antibiotic treatment and easily reoccur [2]. In order to get a higher power of statistical analysis, metaanalysis were used in the current study to combine p-values obtained from individual analysis of datasets extracted from 10 microarray-based datasets which investigate transcriptomic data of mammary gland tissue infected by S. aureus in dairy cows. 185 seneg showed significantly differentially expressed after meta-analysis (44 genes down and 141 genes up regulate respecyleeit). Sub-Network Enrichment Analysis (SNEA) were used to predefine gene sets which have more significant expression changes downstream targets using pathway studio software [3] on differentially expressed genes. Direct regulatory network between the SENA gene seeds were retrieved and displayed by Pathway studio software. Twenty-two critical genes including extracellular proteins such as: C-X-C motif chemokine ligand 8 (CXCL8), Interleukine 10 (IL10), C -C motif chemokine ligand 3 ( CCL2) and membrane protein such as: Toll like receptor 2 (TLR2) were detected through applying 12 different ranking algorithms of Cytohubba plugin in Cytoscape software on direct regulatory network of SNEA gene seeds . |
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| کلیدواژه‌های انگلیسی مقاله |
Meta-analysis, Microarray, Transcriptom, S.aureus, SNEA |
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| نویسندگان مقاله |
Somayeh Sharif - Isfahan University of Technology, Isfahan
Abbas Pakdel - Isfahan University of Technology, Isfahan
Esmaeil Ebrahimie - Shiraz University, Shiraz
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| نشانی اینترنتی |
http://www.icb7.ir |
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| زبان مقاله منتشر شده |
en |
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